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Herzog hfp 339 manual treadmill5/27/2023 To correct for an abnormally high or low serum albumin the following formula can be used:Ĭorrected calcium (mg/dL) = measured total serum calcium (mg/dL) + or Corrected calcium (mM) = measured total serum Ca (mM) + Ĭhanges in blood pH can also alter the equilibrium constant of the albumin-calcium complex: Acidosis reduces binding and alkalosis enhances binding. Conversely when serum albumin levels are low, total serum calcium may be falsely low. Consequently, a falsely elevated total serum calcium may be reported. Hypercalcemia is therefore often defined as a total serum calcium (bound plus ionized) greater than 10.6 mg/dl (2.65 mM) or an ionized serum calcium greater than 5.3 mg/dl (1.3 mM) but values may vary between laboratories.ĭehydration, or hemoconcentration during venipuncture, may elevate total serum albumin whereas ionized calcium may remain normal. Only the ionized calcium is metabolically active i.e., subject to transport into cells, but most laboratories report total serum calcium concentrations. Partly bound to plasma proteins (about 45%), notably to albumin partly bound to small anions such as phosphate and citrate (about 10%) partly in the free or ionized state (about 45%).
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